Tosedostat: inhibiting aminopeptidases in cancers

Tweet asked: AMINOPEPTIDASES AND THEIR INHIBITION:Aminopeptidases are zinc dependent enzymes that are made and released by the glands of the small intestine. These proteins catalyze the hydrolysis of various amino acids from the -NH2 terminal of proteins and hence the use of inhibitors which would block their functions to target protein handling becomes an attractive approach in various diseases and especially in cancers. One example of the above statement is the therapeutic use and success of aminopeptidase inhibitors in the treatment of myeloma cancer cells where these molecules disrupt the immunoglobulins folding . Tosedostat is one such aminopeptidase inhibitor that